solvent-free preparation of novel 2-[phenyl (pyridine-2-ylamino) methyl] phenols as pseudo-betti processor for natural products
نویسندگان
چکیده
conclusions we have developed a new, simple, and efficient method for one-pot aminoalkylation of active phenol compounds with various imines prepared from 2-aminopyrimidine and benzaldehydes in good to high yields (40%-97%). materials and methods all starting materials were purchased from merck and aldrich companies. the ir spectra were recorded on a perkin-elmer rxi infrared spectrometer. results the reaction is convenient, operationally simple, proceeds quickly, and does not need solvents or expensive starting materials. the structures of the products were characterized by their spectral (1h nmr and ir) data. objectives we decided to report the synthesis of a series of novel n-heteroaryl-arylmethyl phenols via a simple three-component, one-pot method, using aromatic aldehydes, heteroaryl amines, and phenols in the absence of any acid catalysts and under solvent-free conditions. background 2-aminopyridine and benzaldehydes mixture readily reacted with phenols at 80°c without any solvents to produce novel 2-[phenyl (pyridine-2-yl amino (methyl] phenol derivatives as pseudo-betti products in good to high yields. these compounds are efficient processor for synthesis of the natural products.
منابع مشابه
Solvent-Free Preparation of Novel 2-[Phenyl (Pyridine-2-Ylamino) Methyl] Phenols as Pseudo-Betti Processor for Natural Products
BACKGROUND 2-Aminopyridine and benzaldehydes mixture readily reacted with phenols at 80°C without any solvents to produce novel 2-[phenyl (pyridine-2-yl amino (methyl] phenol derivatives as pseudo-Betti products in good to high yields. These compounds are efficient processor for synthesis of the natural products. OBJECTIVES We decided to report the synthesis of a series of novel N-heteroaryl-...
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عنوان ژورنال:
jundishapur journal of natural pharmaceutical productsجلد ۹، شماره ۴، صفحات ۰-۰
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